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Authors:
Eran Choman, Michael K. Gould, MD, MS, Pan-Chyr Yang, MD, PhD, David Morgenstern, PhD
BACKGROUND
Asia has the highest incidence of lung cancer and lung cancer mortality in the world and is estimated to have the largest increase in lung cancer incidence of all regions by 2040 (more than Europe and NA combined). The incidence of lung cancer among non-smokers in Asia (particularly East Asia) is substantially higher than in Europe and NA, and based on this difference, it would be intriguing to include never smokers in population-based screening algorithms currently under exploration.
Conclusions
The model demonstrated a highly increased odds ratio compared to opportunistic selection in ever smokers (x5) and never smokers (x6) subpopulations, suggesting a single model can be used as a pre-screening tool to identify elevated risk populations. Furthermore, the model showed increased performance in detection of earlier-stage cancers (>50% improvement).
